4^th International Conference on Pharmaceutical Research
&
Innovations in Pharma Industry November 12-13, 2021 Vancouver, Canada

Biography:

El-Abd obtained her Ph.D degree from Liverpool University, UK in 2002. She established the molecular biology unit in the medical technology center in Egypt and the faculty of science in University of Hail (KSA). She held many leadership positions inside and outside Egypt. In 2010 she was classified as Number 59 among top 100 health professionals. She published more than 30 researchs and has 80 Genank registries. El-Abd is an editor and reviewer in many international journals. She is a member in many professional national and international societies. She awarded several national and international awards.

Abstract:

Background and purpose: In vivo, ectoine single dose showed post-irradiation protective effects via modulation of inflammatory and oxidative stress pathways. The current study aims to explore the possible accumulative pre-irradiation protective effect(s) of ectoine.

Experimental approach: Forty female Swiss albino mice (20–22 gm) divided into four groups; controls (injected intraperitoneally for ten days with 0.2 ml saline), ectoine groups injected with 20 mg/kg of ectoine for ten days), irradiated groups (received six Gy whole body x-irradiation single dose then injected with saline for ten days), ectoine irradiated groups (injected with ectoine for ten days then irradiated). Animals sacrificed on day seven, and 14 (five animals each). Hearts examined for histological changes and immunostained for Bax. Ectoine concentration in hearts measured by HPLC. Serum cardiac troponin T (cTnT), total antioxidant capacity (T-AOC), and apoptosis inducing factor (AIF) evaluated by ELISA. Key results: Heart histological changes documented in 40% of the 7- & 14-days post irradiation. Ectoine concentrations ( mg/mg of heart weight) was higher in ectoine groups than ectoine irradiated groups ( mg/mg of heart weight) 14-days post treatment. Serum cTnT significantly differed between the 14 days groups (p = 0.032). Apoptosis inducible factor (AIF) significantly increased in ectoine irradiated group (at 14 days) than those of control (p = 0.014), irradiated (p = 0.020), and ectoine (p = 0.033) groups. Bax showed strong to moderate immunostaining in ectoine and irradiated groups.

Conclusion and implications: Ectoine have pre-irradiation accumulative effects on heart via modulation of apoptosis.

Biography:

Muhammad Jehangir has 13 years diversified experience of Quality Control, Quality Assurance, Registration Affairs, Product development and Pharmaceutical manufacturing, Process Planning, Method development, Method validation, Statistical Methodology, Process & Cleaning Validation, Equipment Validation etc. Certificate Courses on cGMP, cGLP, Process Validation, CTD Documents, ISO 9001:2008, 13485-2003,14001-2004 have strong scientific, analytical, statistical, managerial and training skills. Currently he is working as a Senior Manager Quality Control and validation for Novamed Pharmaceuticals.It is toll manufacturing oriented company, manufacturing of companies like Getz Pharma, ICI, SEARLE, Macter, Ray, and for Sanofi-Aventis. He is also looking after the Quality of Novamed Healthcare, the nutraceutical and cosmeceutical manufacturing plant.

Abstract:

The evaluation of pharmaceutical raw materials and finished products for impurities and degradation products is an essential part of the drug development and manufacturing testing process. Additionally, toxicological information must be obtained on any drug-related impurity that is present at a concentration of greater than 0.1% of that of the active pharmaceutical ingredient (API). In pharmaceutical QC and manufacturing, impurity analysis has traditionally been performed by HPLC with UV, PDA, or MS detection. As it is essential to detect and measure all of the impurities in the sample, it is necessary to have a high resolution separation process. This usually involves long analysis times resulting in low throughput. As candidate pharmaceutical compounds become more potent and are dosed at lower and lower levels, ever more sensitive assays are needed to detect and measure impurities. The low throughput of HPLC can become the rate-limiting step in product release testing or process evaluation. Since much of the process of impurity identification involves the coupling of LC to sophisticated MS, any reduction in analysis time will result in a more efficient use of these significant investments. Analytical technology advances such as UPLC and UPC offer significant improvements in throughput and sensitivity, with benefits to the process of product release and identification of drug-related impurities. The most characteristic feature of the development in the methodology of pharmaceutical and biomedical analysis during the past 25 years is that HPLC became undoubtedly the most important analytical method for identification and quantification of drugs, either in their active pharmaceutical ingredient or in their formulations during the process of their discovery, development and manufacturing.

Biography:

Gayatri Gautam Varma completed his PhD on polymers at the University of Ulm in 1993, where he then worked as a post-doctoral researcher. He has been employed at Robert Bosch GmbH since 1995. Until 2003, he was responsible for new functional materials in the Central Research Division. From 2003 to 2016, he founded and managed the newly established Bosch Lab Systems division for automation solutions in formulation development.

Abstract:

Skin of the newborn babies differs from that of an adult in several ways. Baby’s skin is more susceptible to trauma and infection and requires special care. As a parent, everyone wants best products for their child. That includes giving them the best skin care routine to keep baby skin soft and healthy. Some ingredients of baby products can cause sensitive skin to become irritated, and certain others can even be absorbed into little one’s body. For this reason, it’s important to know what ingredients are in the products you use on baby’s skin. Selecting safe and effective skin care products for your baby can be overwhelming, but it’s not impossible. Now a days, parents not easily pick up labels with trendy claims, such as “hypoallergenic,” “gentle,” or “organic,” try learning about ingredients that can cause skin irritation if baby shows signs of a rash or reaction. Children are especially vulnerable to chemicals in baby shampoos, lotions, powders, ointments, baby wipes and many other products. Children’s brains, nervous systems and other body organs are still developing, and so these chemical substances that have a small effect on adults can contribute to developmental problems in children. Babies also ingest products that are meant for external use only by putting their fingers, hands, toes, toys and other objects into their mouths. Many personal care baby products contain “penetration enhancers” which further increase the absorption of chemicals through the skin. Some of the known health effects of the more harmful ingredients include developmental problems, cancer, reproductive problems, mutations, nervous system disorders, inflammation, allergy and even death. Other harmful ingredients may irritate the baby’s skin, eyes, respiratory tract or digestive tract. [13] So my aim to prepare a herbal oil formulation as baby product which may produce less or no harm on to the baby’s skin & help them to grow mentally and physically well & healthy.

Biography:

Smriti Sahu has completed her M.Pharm at the age of 24 years from AKTU Lucknow in Pharmaceutical Chemistry having an experience of 10 years. She is the presently working as Assistant Professor of ITS College of Pharmacy, a premier Pharmaceutical academic organization. She has published several papers in reputed journals, presented poster in various International and National conferences and has been serving as an lifetime memeber of various Pharmaceutical regulatory bodies since last 10 years.

Abstract:

The ongoing prevalence of various diseases and pathogens requires the development of new effective pharmacological agents. This thought suggested us to get insight into thiazolidinones and comprehensively review this molecule. The present review provides a summary of structural features, synthetic methodologies, and reactions of 4 thiazolidinones. 4- thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. Structural modifications on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating the different groups and moieties may pave the way for the future research. Essentially it is a three component reaction involving an amine, a carbonyl compound, and a α-mercaptoalkanoic acid, occurring either in a one-pot three-component condensation or a two-step reaction cyclisation reaction going through imine or Schiff’s base formation. This reaction is a cyclisation reaction generating water molecule in a solvent based synthesis. This water molecule sometimes prevent ring cyclisation. Selectfluor catalyst, on other hand catalyses solvent free mediated synthesis with stirring at varying temperatures resulting in ring cyclisation of 4- thiazolidinones and various other hetrocyclic rings, whose synthesis is a lot affected by internal formation of water molecule which otherwise hydrolyses it back. The chemistry of thiazolidinones has drawn scientific interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti-inflammatory, anti-parasitic, hypnotic and anti-cancer.