Smriti Sahu
Assistant Professor
Title: Selectfluor mediated solvent free Synthesis of 4-Thiazolidinones
Biography
Biography: Smriti Sahu
Abstract
The ongoing prevalence of various diseases and pathogens requires the development of new effective pharmacological agents. This thought suggested us to get insight into thiazolidinones and comprehensively review this molecule. The present review provides a summary of structural features, synthetic methodologies, and reactions of 4 thiazolidinones. 4- thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. Structural modiï¬cations on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating the different groups and moieties may pave the way for the future research. Essentially it is a three component reaction involving an amine, a carbonyl compound, and a α-mercaptoalkanoic acid, occurring either in a one-pot three-component condensation or a two-step reaction cyclisation reaction going through imine or Schiff’s base formation. This reaction is a cyclisation reaction generating water molecule in a solvent based synthesis. This water molecule sometimes prevent ring cyclisation. Selectfluor catalyst, on other hand catalyses solvent free mediated synthesis with stirring at varying temperatures resulting in ring cyclisation of 4- thiazolidinones and various other hetrocyclic rings, whose synthesis is a lot affected by internal formation of water molecule which otherwise hydrolyses it back. The chemistry of thiazolidinones has drawn scientiï¬c interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti-inflammatory, anti-parasitic, hypnotic and anti-cancer.