Pharma Research and Development

Gus R Rosania as Principal Investigator of the Subcellular Drug Transport Lab, is transforming the development of new drug formulations, by elucidating the micro pharmacokinetic properties of drugs in their biological, tissue microenvironments. His research group has pioneered new cheminformatic (mathematical modeling and simulation-based) approaches to the design of small molecule drugs with optimal permeability and intracellular accumulation properties, as well as application of hyperspectral Raman imaging approaches to discover new transport and disposition mechanisms acting at cellular and subcellular levels. His major contributions to pharmaceutical sciences is that his research group has discovered the most potent small molecule drug targeting mechanisms that has ever been identified to date, by studying the mechanisms of intracellular drug crystal formation. This knowledge is now being applied to the invention of new pharmaceutical formulation approaches that are poised to transform the manner in which drugs and formulations are designed, developed and regulated.